基于芝加哥的全国先天性弓形虫病协作研究中先天性弓形虫病患儿母亲的脉络膜视网膜病变。
Chorioretinal lesions in mothers of children with congenital toxoplasmosis in the National Collaborative Chicago-based, Congenital Toxoplasmosis Study.
作者信息
Noble A Gwendolyn, Latkany Paul, Kusmierczyk Jaroslaw, Mets Marilyn, Rabiah Peter, Boyer Kenneth, Jalbrzikowski Jessica, Wroblewski Kristen, Karrison Theodore, Swisher Charles N, Mieler William F, Meier Paul, McLeod Rima
机构信息
Department of Ophthalmology and Visual Sciences, The University of Chicago, Chicago, IL.
出版信息
Sci Med (Porto Alegre). 2010;20(1):20-26.
AIMS
To determine whether mothers of children with congenital toxoplasmosis have chorioretinal lesions consistent with toxoplasmosis. METHODS: Prospective cohort study. Ophthalmologists in our study have examined 173 children with congenital toxoplasmosis in a hospital outpatient setting. These children were referred to us by their primary care physicians. One hundred and thirty mothers of these children had retina examinations of both eyes at least once. Main outcome measure was lesion(s) consistent with ocular toxoplasmosis. RESULTS: Of 130 mothers examined between 1991-2005, 10 (7.7%, 95% Confidence Interval 3.8%, 13.7%) had chorioretinal lesions which likely represent resolved toxoplasmic chorioretinitis. Most of these were small peripheral chorioretinal lesions. None reactivated between 1991-2005. CONCLUSIONS: Chorioretinal lesions consistent with quiescent ocular toxoplasmosis occur in mothers of children with congenital toxoplasmosis in the United States.
目的
确定先天性弓形虫病患儿的母亲是否患有与弓形虫病相符的脉络膜视网膜病变。方法：前瞻性队列研究。我们研究中的眼科医生在医院门诊环境中检查了173名先天性弓形虫病患儿。这些患儿由他们的初级保健医生转诊至我们处。其中130名患儿的母亲至少接受过一次双眼视网膜检查。主要观察指标为与眼部弓形虫病相符的病变。结果：在1991年至2005年间接受检查的130名母亲中，10名（7.7%，95%置信区间3.8%，13.7%）有脉络膜视网膜病变，这可能代表已消退的弓形虫性脉络膜视网膜炎。其中大多数是周边小的脉络膜视网膜病变。在1991年至2005年间，无一例复发。结论：在美国，先天性弓形虫病患儿的母亲中存在与静止性眼部弓形虫病相符的脉络膜视网膜病变。
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