Department of Ophthalmology, University of California, San Francisco, CA, USA.
Curr Eye Res. 2012 Jun;37(6):486-91. doi: 10.3109/02713683.2012.669006.
To compare lens vault between open-angle and narrow-angle eyes in African-, Caucasian-, Hispanic-, Chinese- and Filipino-Americans.
In this prospective study, 436 patients with open angle and narrow angle based on the Shaffer gonioscopic grading classification underwent anterior-segment optical coherence tomography. The Zhongshan Angle Assessment Program was used to calculate lens vault. The narrow-angle group included 32 Chinese-Americans, 22 Filipino-Americans, 26 African-Americans, 24 Hispanic-Americans and 73 Caucasian-Americans. The open-angle group included 56 Chinese-Americans, 29 Filipino-Americans, 45 African-Americans, 27 Hispanic-Americans and 102 Caucasian-Americans. Linear mixed effect regression models, accounting for the use of both eyes and adjusting for age, sex, pupil diameter and spherical equivalent, were used to test for the ethnicity and angle coefficients. Tukey's multiple comparison test was used for pairwise comparisons among the open-angle racial groups.
Significant difference in lens vault was found among the open-angle racial groups (P = 0.022). For the open-angle patients, mean values for the lens vault measurements were 265 ± 288 µm for Chinese-Americans, 431 ± 248 µm for Caucasian-Americans, 302 ± 213 µm for Filipino-Americans, 304 ± 263 µm for Hispanic-Americans and 200 ± 237 µm for African-Americans. Using Tukey's multiple comparison for pairwise comparisons among the open-angle racial groups, a significant difference was found between African-American and Caucasian-Americans groups (P < 0.001). P values for the rest of the pairwise comparisons were not statistically significant. No significant difference was found among the narrow-angle racial groups (P = 0.14). Comparison between the open angle and narrow angle within each racial group revealed significant difference for all racial groups (P < 0.05).
Among all the ethnicities included in this study, narrow-angle eyes have greater lens vault compared to open-angle eyes. With the exception of the comparison between African-Americans and Caucasian-Americans, differences in lens vault measurements among the racial groups with open angle were statistically insignificant. Our data suggest that other factors may play a greater role in predisposing Asian races to angle closure.
比较非裔美国人、白种人、西班牙裔、美籍华人及菲律宾裔美国人的开角眼和窄角眼的晶状体拱顶。
在这项前瞻性研究中，436 名根据 Shaffer 房角分级分类为开角和窄角的患者接受了眼前节光学相干断层扫描。采用中山角评估程序计算晶状体拱顶。窄角组包括 32 名美籍华人、22 名菲律宾裔美国人、26 名非裔美国人、24 名西班牙裔美国人和 73 名白种人。开角组包括 56 名美籍华人、29 名菲律宾裔美国人、45 名非裔美国人、27 名西班牙裔美国人和 102 名白种人。线性混合效应回归模型，考虑到双眼的使用并调整年龄、性别、瞳孔直径和等效球镜，用于测试种族和角度系数。采用 Tukey 多重比较检验进行开角种族组间的两两比较。
开角种族组间的晶状体拱顶存在显著差异（P = 0.022）。对于开角患者，晶状体拱顶测量的平均值为美籍华人 265±288 µm，白种人 431±248 µm，菲律宾裔美国人 302±213 µm，西班牙裔 304±263 µm，非裔美国人 200±237 µm。采用 Tukey 多重比较进行开角种族组间的两两比较，非裔美国人和白种人组间差异有统计学意义（P < 0.001）。其余组间比较的 P 值均无统计学意义。窄角种族组间无显著差异（P = 0.14）。在每个种族组内，开角和窄角之间的比较显示所有种族组均有显著差异（P < 0.05）。
在所研究的所有种族中，窄角眼的晶状体拱顶大于开角眼。除非裔美国人和白种人之间的比较外，开角种族间晶状体拱顶测量值的差异无统计学意义。我们的数据表明，其他因素可能在导致亚洲人种发生闭角型青光眼方面发挥更大作用。
