Siguan-Bell Christine S, Chansangpetch Sunee, Perez Claudio I, Kutzscher Anne, Wang Dandan, He Mingguang, Oldenburg Catherine, Hee Michael R, Lin Shan C
Department of Ophthalmology, University of California, San Francisco, CA, USA.
Department of Ophthalmology and Visual Sciences, University of the Philippines-Philippine General Hospital, Manila, Philippines.
Transl Vis Sci Technol. 2019 Apr 4;8(2):11. doi: 10.1167/tvst.8.2.11. eCollection 2019 Apr.
We compare anterior segment characteristics of Filipino- versus Chinese- and Caucasian-Americans to describe the differences in risk factors among each ethnic group.
A cross-sectional study was conducted among Filipino, Chinese, and Caucasian subjects without glaucoma who underwent a standardized set of ocular examinations and anterior segment optical coherence tomography (Visante ASOCT) imaging. Zhongshan Angle Assessment Program (ZAAP) 4 was used for ASOCT image analysis. The following quantitative parameters wereobtained from ZAAP: (1) angle opening distance (AOD500, AOD750), angle recess area at 750 μm (ARA), and trabecular-iris space area at 500 and 750 μm (TISA500, TISA750); (2) iris parameters, including iris thickness at 750 μm from the scleral spur (IT750), iris area (IArea), iris curvature or convexity (ICurv), and pupil diameter; 3) anterior chamber parameters; and (4) lens vault.
The Filipino (122 eyes), Chinese (121 eyes), and Caucasian (111 eyes) subject groups were similar in terms of demographic and clinical characteristics. We reported pairwise comparisons of Filipino parameter values to Chinese or Caucasian values, represented as B-coefficients and values. In multivariate analysis, Filipinos had narrower angles than Caucasians (AOD750, TISA 500, TISA 750, ARA, < 0.001). Filipinos had thicker and more convex irises than Caucasians (IT750, IT 2000, ICurv < 0.003). Angle and iris parameters were similar overall for Filipino and Chinese.
Filipinos appear to have more convex and thicker irises, smaller lens vault and narrower angles compared to Caucasians. Filipino eyes closely resembled Chinese eyes with similar iris and angle parameters.
The anatomic angle parameters of Filipinos may contribute to angle closure risk among this population, thus ASOCT and thorough angle analysis is recommended in this population.
我们比较菲律宾裔、华裔和高加索裔美国人的眼前节特征，以描述各民族之间危险因素的差异。
对未患青光眼的菲律宾裔、华裔和高加索裔受试者进行横断面研究，这些受试者接受了一套标准化的眼科检查和眼前节光学相干断层扫描（Visante ASOCT）成像。中山房角评估程序（ZAAP）4用于ASOCT图像分析。从ZAAP中获得以下定量参数：（1）房角开放距离（AOD500、AOD750）、750μm处的房角隐窝面积（ARA）以及500和750μm处的小梁-虹膜间隙面积（TISA500、TISA750）；（2）虹膜参数，包括距巩膜突750μm处的虹膜厚度（IT750）、虹膜面积（IArea）、虹膜曲率或凸度（ICurv）以及瞳孔直径；3）前房参数；以及（4）晶状体拱高。
菲律宾裔（122只眼）、华裔（121只眼）和高加索裔（111只眼）受试者组在人口统计学和临床特征方面相似。我们报告了菲律宾裔参数值与华裔或高加索裔参数值的成对比较，以B系数和P值表示。在多变量分析中，菲律宾裔的房角比高加索裔窄（AOD750、TISA 500、TISA 750、ARA，P<0.001）。菲律宾裔的虹膜比高加索裔更厚且更凸（IT750、IT 2000、ICurv，P<0.003）。菲律宾裔和华裔的房角和虹膜参数总体相似。
与高加索裔相比，菲律宾裔的虹膜似乎更凸、更厚，晶状体拱高更小，房角更窄。菲律宾裔的眼睛与华裔的眼睛在虹膜和房角参数方面相似。
菲律宾裔的解剖学房角参数可能导致该人群发生房角关闭的风险，因此建议对该人群进行ASOCT检查和全面的房角分析。
