Département de Chimie, CINaM CNRS UMR 7325, Aix-Marseille Université, Marseille, France.
J Med Chem. 2012 Jun 14;55(11):5642-6. doi: 10.1021/jm300534u. Epub 2012 May 21.
A novel bitriazolyl acyclonucleoside was discovered to exhibit powerful antiproliferative effects on different cancer cell lines through caspase-dependent apoptosis and at the same time stimulate the immune response in dendritic cells via Toll-like receptor 7 (TLR7) signaling. This promising compound with dual anticancer and immunomodulatory activity may represent a new generation of highly efficacious drug candidates for use in cancer therapy.
一种新型的双三唑基环核苷被发现通过半胱天冬酶依赖性细胞凋亡对不同的癌细胞系表现出强大的抗增殖作用，同时通过 Toll 样受体 7（TLR7）信号刺激树突状细胞的免疫反应。这种具有双重抗癌和免疫调节活性的有前途的化合物可能代表新一代高效的癌症治疗候选药物。
