Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
Ultrasound Med Biol. 2012 Jul;38(7):1271-83. doi: 10.1016/j.ultrasmedbio.2012.02.028. Epub 2012 May 12.
Acoustic radiation force (ARF)-based methods have been demonstrated to be a viable tool for noninvasively estimating tissue elastic properties, and shear wave velocimetry has been used to measure quantitatively the stiffening and relaxation of myocardial tissue in open-chest experiments. Dynamic stiffness metrics may prove to be indicators for certain cardiac diseases, but a clinically viable means of remotely generating and tracking transverse wave propagation in myocardium is needed. Intracardiac echocardiography (ICE) catheter-tip transducers are demonstrated here as a viable tool for making this measurement. ICE probes achieve favorable proximity to the myocardium, enabling the use of shear wave velocimetry from within the right ventricle throughout the cardiac cycle. This article describes the techniques used to overcome the challenges of using a small probe to perform ARF-driven shear-wave velocimetry and presents in vivo porcine data showing the effectiveness of this method in the interventricular septum.
基于声辐射力（ARF）的方法已被证明是一种可行的工具，可用于无创估计组织弹性特性，剪切波速度测量已被用于在开胸实验中定量测量心肌组织的僵硬和松弛。动态硬度指标可能被证明是某些心脏病的指标，但需要一种可行的临床手段来远程产生和跟踪心肌中的横向波传播。心内超声心动图（ICE）导管尖端换能器在这里被证明是一种可行的工具，可以进行这种测量。ICE 探头能够很好地接近心肌，从而能够在整个心动周期内从右心室内部使用剪切波速度测量。本文描述了克服使用小探头进行 ARF 驱动的剪切波速度测量的挑战的技术，并展示了体内猪数据，显示了该方法在室间隔中的有效性。
