Valverde I, Vandermeers A, Anjaneyulu R, Malaisse W J
Science. 1979 Oct 12;206(4415):225-7. doi: 10.1126/science.225798.
Pancreatic islets contain calmodulin. The protein binds to a particulate fraction derived from the islets and stimulates adenylate cyclase activity in this subcellular fraction, both phenomena being activated by ionized calcium. A calcium-dependent stimulation of adenylate cyclase by endogenous calmodulin may contribute to the accumulation of adenosine 3',5'-monophosphate evoked by insulin releasing agents in the islet cells.
胰岛中含有钙调蛋白。该蛋白与从胰岛中提取的微粒部分结合，并刺激该亚细胞部分中的腺苷酸环化酶活性，这两种现象均由离子钙激活。内源性钙调蛋白对腺苷酸环化酶的钙依赖性刺激可能有助于胰岛细胞中胰岛素释放剂引起的3',5'-单磷酸腺苷的积累。
