Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.
Mol Immunol. 2012 Aug;52(1):30-7. doi: 10.1016/j.molimm.2012.04.009. Epub 2012 May 14.
Granulocyte-macrophage colony stimulating factor (GM-CSF) is a cytokine that functions as a hematopoietic growth factor for the generation of white blood cells and is used clinically to stimulate hematopoiesis following chemotherapy. Apart from stimulating production of granulocytes and monocytes/macrophages, GM-CSF has also long been used for in vitro survival/generation of dendritic cells (DCs) from monocytes and bone marrow cells. Evidence has emerged pointing to an additional role for GM-CSF in regulating the function and differential development of several DC subsets. These newly ascribed functions of GM-CSF may underscore its importance in immunity against pathogens as well as initiating/mediating immunopathology in chronic inflammation. Here we summarize recent advances on the role of GM-CSF in regulating the development and function of DC subsets and discuss the biological significance of these new findings.
粒细胞-巨噬细胞集落刺激因子（GM-CSF）是一种细胞因子，作为一种造血生长因子，可促进白细胞的生成，临床上用于化疗后刺激造血。除了刺激粒细胞和单核细胞/巨噬细胞的产生外，GM-CSF 还长期用于体外从单核细胞和骨髓细胞中存活/生成树突状细胞（DC）。有证据表明，GM-CSF 在调节几种 DC 亚群的功能和分化发育方面具有额外的作用。GM-CSF 的这些新功能可能突出了其在对抗病原体以及在慢性炎症中启动/介导免疫病理中的重要性。在这里，我们总结了 GM-CSF 在调节 DC 亚群发育和功能中的作用的最新进展，并讨论了这些新发现的生物学意义。
