Department of Biology, University of Utah, Salt Lake City, UT, USA.
J Comp Physiol B. 2013 Jan;183(1):43-50. doi: 10.1007/s00360-012-0670-y. Epub 2012 May 12.
Diet selection in mammalian herbivores is thought to be primarily governed by intrinsic properties of food, such as nutrient and plant secondary compound (PSC) contents, and less so by environmental factors. However, several independent lines of evidence suggest that the toxicity of PSCs is mediated, in part, by ambient temperature and that the effect of small changes in ambient temperature is on par with several fold changes in PSC concentration. This review describes the disparate lines of evidence for temperature-dependent toxicity and the putative mechanisms causing this phenomenon. A model is described that integrates thermal physiology with temperature-dependent toxicity to predict maximal dietary intake of plant secondary compounds by mammalian herbivores. The role of temperature-dependent toxicity is considered with respect to the observed changes in herbivorous species attributed to climate change. Possible future investigations and the effects of temperature-dependent toxicity on other endotherms are presented. Temperature-dependent toxicity has the potential to apply to all endotherms that consume toxins. The effects of temperature-dependent toxicity will likely be exacerbated with increasing ambient temperatures caused by climate change.
哺乳动物草食动物的饮食选择被认为主要受食物内在特性的控制，如营养物质和植物次生化合物 (PSC) 的含量，而受环境因素的影响较小。然而，有几项独立的证据表明， PSC 的毒性部分受环境温度的调节，并且环境温度的微小变化的影响与 PSC 浓度的几倍变化相当。本综述描述了与温度相关的毒性的不同证据以及导致这种现象的潜在机制。描述了一个将热生理学与温度相关的毒性相结合的模型，以预测哺乳动物草食动物对植物次生化合物的最大膳食摄入量。考虑了温度相关毒性的作用，以及由于气候变化而导致的草食性物种的观察到的变化。提出了可能的未来研究以及温度相关毒性对其他恒温动物的影响。温度相关的毒性有可能适用于所有消耗毒素的恒温动物。由于气候变化导致的环境温度升高，温度相关的毒性的影响可能会加剧。
