Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China , Qingdao 266003, People's Republic of China.
J Nat Prod. 2012 May 25;75(5):920-7. doi: 10.1021/np3000443. Epub 2012 May 14.
Two new epipolythiodioxopiperazines, named chetracins B and C (1 and 2), and five new diketopiperazines, named chetracin D (4) and oidioperazines A-D (5, 10, 12, and 13), were isolated from the fungus Oidiodendron truncatum GW3-13, along with six known compounds (3, 6, 7, 8, 9, and 11). Their structures were elucidated by extensive NMR, MS, and CD analyses, as well as chemical transformation. An in vitro MTT cytotoxicity assay revealed potent biological activity for 1 in the nanomolar range against a panel of five human cancer lines.
两种新的硫代二氧杂环戊二酮哌嗪，命名为切托菌素 B 和 C（1 和 2），以及五种新的二酮哌嗪，命名为切托菌素 D（4）和 oidioperazines A-D（5、10、12 和 13），从真菌 Oidiodendron truncatum GW3-13 中分离出来，同时分离出六种已知化合物（3、6、7、8、9 和 11）。它们的结构通过广泛的 NMR、MS 和 CD 分析以及化学转化得到阐明。体外 MTT 细胞毒性测定显示，化合物 1 对五种人类癌细胞系具有纳摩尔级别的强大生物活性。
