来源于深海真菌黄蓝指突孢菌 SCSIO F457 的细胞毒性吲哚二酮哌嗪类化合物。
Cytotoxic indole diketopiperazines from the deep sea-derived fungus Acrostalagmus luteoalbus SCSIO F457.
机构信息
CAS Key Laboratory of Marine Bio-resources Sustainable Utilization, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China.
出版信息
Bioorg Med Chem Lett. 2012 Dec 1;22(23):7265-7. doi: 10.1016/j.bmcl.2012.08.115. Epub 2012 Sep 28.
Two new indole diketopiperazines, namely luteoalbusins A-B (1-2), along with eight known ones (3-10), were isolated from the fungus Acrostalagmus luteoalbus SCSIO F457 originated from deep-sea sediment. Their structures were determined by 1D/2D NMR, MS, and CD data analyses. Each of these compounds was evaluated for their cytotoxic activities against SF-268, MCF-7, NCI-H460, and HepG-2 cell lines, and compounds 1-5 showed significant cytotoxicties against all four cancer cell lines. Moreover, new compounds 1 and 2 had more potent cytotoxicity than the other ones and cisplatin.
两种新的吲哚二酮哌嗪类化合物，即 luteoalbusins A-B（1-2），与另外八种已知化合物（3-10）一起，从深海沉积物中分离出来的真菌 Acrostalagmus luteoalbus SCSIO F457 中分离得到。通过 1D/2D NMR、MS 和 CD 数据分析确定了它们的结构。对这些化合物进行了抗 SF-268、MCF-7、NCI-H460 和 HepG-2 细胞系的细胞毒性活性评价，化合物 1-5 对所有四种癌细胞系均显示出显著的细胞毒性。此外，新化合物 1 和 2 比其他化合物和顺铂具有更强的细胞毒性。
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