Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, CA 91766, USA.
Anticancer Agents Med Chem. 2012 Dec;12(10):1306-13. doi: 10.2174/187152012803833062.
Breast cancer is one of the most common types of cancer in women, and is the second leading cause of cancer-related deaths in the United States. Chemoprevention using phytoestrogens (PEs) for breast cancer may be a valid strategy. PEs are phytochemicals with estrogen-like structures and can be classified into four types: isoflavones, lignans, stilbenes and coumestans. They are widely distributed in diet and herbs and have shown anti-cancer activity via mechanisms including estrogen receptor modulation, aromatase inhibition, and anti-angiogenesis. Genistein, daidzein and resveratrol are some of the most studied PE examples. Quality control in product manufacturing and clinical study design is a critical issue in developing them as clinically effective chemopreventive agents for breast cancer.
乳腺癌是女性最常见的癌症类型之一，也是美国癌症相关死亡的第二大主要原因。使用植物雌激素 (PEs) 进行乳腺癌化学预防可能是一种有效的策略。PEs 是具有雌激素样结构的植物化学物质，可分为四类：异黄酮、木脂素、芪和香豆素。它们广泛存在于饮食和草药中，并通过包括雌激素受体调节、芳香酶抑制和抗血管生成在内的机制显示出抗癌活性。染料木黄酮、大豆苷元和白藜芦醇是研究最多的 PEs 示例之一。在将它们开发为用于乳腺癌的临床有效的化学预防剂的过程中，产品制造和临床研究设计的质量控制是一个关键问题。
