Wego Kamgaing Marius Trésor, Mvondo Marie Alfrede, Poualeu Kamani Sylviane Laure, Minko Essono Stéphane, Wansi Ngnokam Sylvie Lea
Department of Animal Biology, Faculty of Science, University of Dschang, P. O. Box 67 Dschang, Dschang, Cameroon.
Adv Pharmacol Pharm Sci. 2020 Nov 20;2020:8869281. doi: 10.1155/2020/8869281. eCollection 2020.
Proliferation is a cellular process strongly linked to the genesis of cancer. Natural substances with antiproliferative activities are currently potential alternatives in the treatment of cancers. , for instance, is a medicinal plant traditionally used in the treatment of cancer. Scientific studies have reported the antioxidant activity of this plant. In addition, the presence of prostate cancer chemopreventive polyphenols was reported in extracts. Therefore, this study was aimed to evaluate the effects of the aqueous extract of leaves on cell proliferation induced by estradiol in ovariectomized female Wistar rats. In this regard, ovariectomized (OVX) rats were cotreated with estradiol valerate (EV) (0.75 mg/kg) and the aqueous extract of leaves. Control groups received either the vehicle (sham-operated animals and the OVX control), EV (0.75 mg/kg) only, or EV (0.75 mg/kg) and tamoxifen (10 mg/kg). Treatments were administered orally for 3 consecutive days, and animals were sacrificed thereafter. Epithelial heights of the uterus and vagina were assessed. Uterine levels of total cholesterol and estradiol were determined as well. Results showed that the aqueous extract of leaves reversed the effects of estradiol as it reduced uterine weight ( < 0.05), uterine ( < 0.05), and vaginal ( < 0.001) epithelium heights. This antiproliferative effect of was associated with reduced tissue (uterine) levels of estradiol ( < 0.001). These results suggest that the aqueous extract of leaves could be a potential alternative treatment for proliferation-related diseases.
细胞增殖是一个与癌症发生密切相关的细胞过程。具有抗增殖活性的天然物质目前是癌症治疗中的潜在替代物。例如，[植物名称]是一种传统上用于治疗癌症的药用植物。科学研究报道了这种植物的抗氧化活性。此外，在[植物名称]提取物中也报道了前列腺癌化学预防多酚的存在。因此，本研究旨在评估[植物名称]叶水提取物对去卵巢雌性Wistar大鼠中雌二醇诱导的细胞增殖的影响。在这方面，将去卵巢（OVX）大鼠与戊酸雌二醇（EV）（0.75mg/kg）和[植物名称]叶水提取物共同处理。对照组分别接受赋形剂（假手术动物和OVX对照）、仅EV（0.75mg/kg）或EV（0.75mg/kg）和他莫昔芬（10mg/kg）。连续3天口服给药，之后处死动物。评估子宫和阴道的上皮高度。还测定了子宫中总胆固醇和雌二醇的水平。结果表明，[植物名称]叶水提取物逆转了雌二醇的作用，因为它降低了子宫重量（P<0.05）、子宫（P<0.05）和阴道（P<0.001）上皮高度。[植物名称]的这种抗增殖作用与组织（子宫）中雌二醇水平降低（P<0.001）有关。这些结果表明，[植物名称]叶水提取物可能是增殖相关疾病的一种潜在替代治疗方法。
