Miguel Servet University Hospital (Instituto Aragonés de Ciencias de la Salud), Zaragoza, Spain.
Ophthalmology. 2012 Aug;119(8):1558-62. doi: 10.1016/j.ophtha.2012.02.031. Epub 2012 May 12.
To perform a longitudinal multivariate analysis of the ability of Moorfields Regression Analysis (MRA) to predict the onset of glaucoma in a population of patients with suspected glaucoma due to appearance of the optic nerve head.
Prospective longitudinal evaluation of a diagnostic test.
Single, randomly selected eye of prospectively recruited patients with suspected glaucoma based on the optic nerve head appearance on stereophotographs and normal baseline visual field results.
The MRA was evaluated at baseline (Heidelberg Retina Tomograph; Heidelberg Engineering, Dossenheim, Germany), and visual field tests were repeated every 6 months. A longitudinal multivariate proportional hazard ratio (HR) analysis was performed, and likelihood ratios and positive and negative predictive values were compared.
Onset of visual field losses.
The study included 230 eyes that were followed up during a mean period of 62±14 months, ranging from 4 to 7 years. The predicted HR (for onset of visual field losses) of the MRA temporal-inferior sector outside normal limits was 3.65 (95% confidence interval [CI], 2.32-5.75; P < 0.0001). An MRA temporal-superior sector outside normal limits had an HR of 3.43 (95% CI, 2.21-5.32; P < 0.0001).
The temporal-inferior and temporal-superior positions of the MRA are highly predictive for the onset of visual field loss in glaucoma suspects.
对 Moorfields 回归分析（MRA）在因视神经头外观而疑似青光眼的患者人群中预测青光眼发作的能力进行纵向多变量分析。
对诊断测试的前瞻性纵向评估。
根据立体照片上视神经头的外观和正常基线视野结果，前瞻性招募的疑似青光眼患者的单只随机选择眼。
在基线时评估 MRA（海德堡视网膜断层扫描仪；海德堡工程，德国多森海姆），并每 6 个月重复进行视野测试。进行了纵向多变量比例风险比（HR）分析，并比较了似然比和阳性及阴性预测值。
视野损失的发作。
本研究纳入了 230 只眼，平均随访时间为 62±14 个月，范围为 4 至 7 年。MRA 颞下区超出正常范围的预测 HR（视野损失发作）为 3.65（95%置信区间[CI]，2.32-5.75；P<0.0001）。MRA 颞上区超出正常范围的 HR 为 3.43（95%CI，2.21-5.32；P<0.0001）。
MRA 的颞下和颞上位置对青光眼疑似患者视野损失的发作具有高度预测性。
