平滑肌瘤：遗传学、辅助生殖、妊娠和治疗进展。
Leiomyoma: genetics, assisted reproduction, pregnancy and therapeutic advances.
机构信息
Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institute of Health, Bethesda, MD, USA.
出版信息
J Assist Reprod Genet. 2012 Aug;29(8):703-12. doi: 10.1007/s10815-012-9784-0. Epub 2012 May 15.
PURPOSE
Uterine leiomyomas are common, benign, reproductive tract tumors affecting a majority of reproductive aged women. They are associated with gynecologic morbidity and detrimentally affect reproductive potential. The etiology of leiomyomas is poorly understood and their diagnosis prior to treatment with Assisted Reproductive Technologies (ART) represents a management dilemma. The purpose of this paper is to review known genetic and molecular contributions to the etiologies of leiomyomas, describe their impact on ART outcomes and reproductive potential, and review alternative therapies and future directions in management.
METHODS
A critical review of the literature pertaining to genetic component of uterine leiomyomas, their impact on ART and pregnancy and leiomyoma therapeutics was performed.
RESULTS
Uterine leiomyomas are characterized by complex molecular mechanisms. Their location and size determines their potential detriment to ART and reproductive function and novel therapeutic modalities are being developed.
CONCLUSION
The high prevalence of uterine leiomyomas and their potential detrimental influence on ART and reproductive function warrants continued well-designed studies to ascertain their etiology, optimal treatment and novel less morbid therapies.
目的
子宫肌瘤是一种常见的良性生殖系统肿瘤，影响大多数育龄期妇女。它们与妇科疾病有关，并对生殖潜能产生不利影响。子宫肌瘤的病因尚不清楚，在使用辅助生殖技术 (ART) 治疗之前对其进行诊断是一个管理难题。本文的目的是回顾已知的遗传和分子因素对子宫肌瘤病因的贡献，描述它们对 ART 结局和生殖潜能的影响，并回顾替代疗法和管理的未来方向。
方法
对与子宫肌瘤遗传成分、对 ART 和妊娠的影响以及子宫肌瘤治疗相关的文献进行了批判性回顾。
结果
子宫肌瘤的特征是复杂的分子机制。它们的位置和大小决定了它们对 ART 和生殖功能的潜在危害，并且正在开发新的治疗方法。
结论
子宫肌瘤的高患病率及其对 ART 和生殖功能的潜在不利影响需要继续进行精心设计的研究，以确定其病因、最佳治疗方法和新的、较少有创性的治疗方法。
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