Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata, Japan.
Wiley Interdiscip Rev Syst Biol Med. 2012 Jul-Aug;4(4):385-99. doi: 10.1002/wsbm.1175. Epub 2012 May 14.
Modern techniques on single-cell and -molecule resolution reveal that gene and protein expressions between cells of an otherwise identical group are stochastic in time, and clonal population of cells display heterogeneity in the abundance of a given protein per cell at any measured time. Today, combinatorially, stochasticity and heterogeneity are considered as biological noise and are essential for generating phenotypic variations, cell fate decisions and amplification of molecular signals. Here, several works from experimental and theoretical aspects that show multimodal biological decisions at single cell and population level are reviewed. The emerging lessons from these studies suggest that, for yielding multimodal decisions, living systems are guided by well-defined nonlinear deterministic processes which are sensitive to specific range of biological parameters.
现代单细胞和单分子分辨率技术表明，即使在同一组细胞中，基因和蛋白质的表达在时间上也是随机的，并且克隆细胞群体在任何给定时间点的给定蛋白质的丰度上都表现出异质性。如今，从组合学的角度来看，随机性和异质性被认为是生物噪声，对于产生表型变异、细胞命运决定和分子信号放大是必不可少的。在这里，我们综述了一些来自实验和理论方面的工作，这些工作表明单细胞和群体水平的多模态生物学决策。这些研究得出的新结论表明，为了产生多模态决策，生命系统受到对特定生物参数范围敏感的明确非线性确定性过程的指导。
