二甲双胍在肥胖、癌症与衰老中的应用：解决争议
Metformin in obesity, cancer and aging: addressing controversies.
作者信息
Berstein Lev M
机构信息
Laboratory of Oncoendocrinology, N.N.Petrov Research Institute of Oncology, St. Petersburg, Russia.
出版信息
Aging (Albany NY). 2012 May;4(5):320-9. doi: 10.18632/aging.100455.
Abstract
Metformin, an oral anti-diabetic drug, is being considered increasingly for treatment and prevention of cancer, obesity as well as for the extension of healthy lifespan. Gradually accumulating discrepancies about its effect on cancer and obesity can be explained by the shortage of randomized clinical trials, differences between control groups (reference points), gender- and age-associated effects and pharmacogenetic factors. Studies of the potential antiaging effects of antidiabetic biguanides, such as metformin, are still experimental for obvious reasons and their results are currently ambiguous. Here we discuss whether the discrepancies in different studies are merely methodological or inherently related to individual differences in responsiveness to the drug.
摘要
二甲双胍是一种口服抗糖尿病药物，目前越来越多地被考虑用于癌症治疗与预防、肥胖症治疗以及延长健康寿命。关于其对癌症和肥胖症影响的差异逐渐积累，这可以通过随机临床试验的缺乏、对照组（参考点）之间的差异、性别和年龄相关效应以及药物遗传学因素来解释。由于显而易见的原因，对抗糖尿病双胍类药物如二甲双胍潜在抗衰老作用的研究仍处于实验阶段，目前其结果尚不明确。在此，我们讨论不同研究中的差异仅仅是方法学上的，还是与个体对药物反应性的差异存在内在关联。
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