人类疟疾的系统免疫学。
Systems immunology of human malaria.
机构信息
Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12441 Parklawn Drive, Rockville, MD 20852, USA.
出版信息
Trends Parasitol. 2012 Jun;28(6):248-57. doi: 10.1016/j.pt.2012.03.006. Epub 2012 May 15.
Abstract
Plasmodium falciparum malaria remains a global public health threat. Optimism that a highly effective malaria vaccine can be developed stems in part from the observation that humans can acquire immunity to malaria through experimental and natural P. falciparum infection. Recent advances in systems immunology could accelerate efforts to unravel the mechanisms of acquired immunity to malaria. Here, we review the tools of systems immunology, their current limitations in the context of human malaria research, and the human 'models' of malaria immunity to which these tools can be applied.
摘要
恶性疟原虫疟疾仍然是全球公共卫生的威胁。人们乐观地认为，可以开发出一种非常有效的疟疾疫苗，部分原因是观察到人类可以通过实验和自然的恶性疟原虫感染获得对疟疾的免疫力。系统免疫学的最新进展可以加速人们努力揭示获得性疟疾免疫的机制。在这里，我们回顾了系统免疫学的工具，以及它们在人类疟疾研究背景下的当前局限性，以及这些工具可以应用于的人类疟疾免疫“模型”。
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