Department of Neonatology, GATA Military School of Medicine, Ankara, Turquía.
Arch Bronconeumol. 2013 Jan;49(1):15-21. doi: 10.1016/j.arbres.2012.03.013. Epub 2012 May 15.
Oxygen-induced lung injury is believed to lead to the development of bronchopulmonary dysplasia in premature infants. We have evaluated the beneficial effects of Nigella sativa oil (NSO) on rats with hyperoxia-induced lung injury.
Thirty newborn Sprague-Dawley rats were randomly divided into 3 groups as hyperoxia (95% O(2)), hyperoxia+NSO and control (21% O(2)). Pups in the hyperoxia+NSO group were administered intraperitoneal NSO at a dose of 4ml/kg daily during the study period. Histopathologic, immunochemical, and biochemical evaluations (superoxide dismutase [SOD], glutathione peroxidase [GSH-Px], malonaldehyde [MDA] and myeloperoxidase [MPO]) were performed.
In the histopathologic and immunochemical evaluation, severity of lung damage was significantly lower in the hyperoxia+NOS group (P<.05). Tissue GSH-Px and SOD levels were significantly preserved, and MDA, MPO levels were significantly lower in the hyperoxia+NSO group (P<.05).
NSO significantly reduced the severity of lung damage due to hyperoxia.
人们认为氧诱导性肺损伤会导致早产儿支气管肺发育不良的发生。我们评估了黑种草籽油（NSO）对高氧诱导性肺损伤大鼠的有益作用。
30 只新生 Sprague-Dawley 大鼠随机分为 3 组：高氧组（95%O₂）、高氧+NSO 组和对照组（21%O₂）。高氧+NSO 组大鼠在研究期间每天接受 4ml/kg 的腹腔内 NSO 治疗。进行组织病理学、免疫化学和生化评估（超氧化物歧化酶[SOD]、谷胱甘肽过氧化物酶[GSH-Px]、丙二醛[MDA]和髓过氧化物酶[MPO]）。
在组织病理学和免疫化学评估中，高氧+NOS 组的肺损伤严重程度显著降低（P<.05）。高氧+NSO 组组织 GSH-Px 和 SOD 水平显著保存，MDA 和 MPO 水平显著降低（P<.05）。
NSO 可显著减轻高氧引起的肺损伤严重程度。
