Turhan Yalçın, Arıcan Mehmet, Karaduman Zekeriya O, Turhal Ozan, Gamsızkan Mehmet, Aydın Davut, Kılıç Bülent, Özkan Korhan
Orthopedics and Traumatology Department, Duzce University Medical Faculty, Duzce, Turkey.
Pathology Department, Duzce University Medical Faculty, Duzce, Turkey.
J Musculoskelet Neuronal Interact. 2019 Sep 1;19(3):362-369.
oil possesses a well-known ability to protect certain organs from oxidative, neoplastic, and inflammatory damage. This study investigated the potential chondroprotective effects of intraarticular injections of oil in a rabbit osteoarthritis model.
Osteoarthritis models were created by performing anterior cruciate ligament transections in 20 New Zealand rabbits. Rabbits were randomly divided into two groups of 10 and given intraarticular injections in their right knees weekly for 5 weeks, beginning in the third week post-operation. Injections given to the first group contained whole oil, whereas the second group was injected with a saline solution. Knee joints were harvested 8 weeks after surgery. Knee joint surfaces were examined macroscopically, and medial femoral condyle sections were examined microscopically.
There was a statistically significant difference in the macroscopic grading results of the groups, with the group having better results (p=0.001). The a group also received significantly better total Osteoarthritis Research Society International (OARSI) scores (p=0.035).
Intraarticular administration of oil has the potential to protect cartilage from degeneration in the early stages of osteoarthritis.
油具有保护某些器官免受氧化、肿瘤和炎症损伤的众所周知的能力。本研究在兔骨关节炎模型中研究了关节内注射油的潜在软骨保护作用。
对20只新西兰兔进行前交叉韧带横断术建立骨关节炎模型。将兔子随机分为两组，每组10只，从术后第三周开始，每周对其右膝进行关节内注射，持续5周。第一组注射的是全油，而第二组注射的是盐溶液。术后8周采集膝关节。对膝关节表面进行宏观检查，对股骨内侧髁切片进行微观检查。
两组的宏观分级结果存在统计学显著差异，油组结果更好（p = 0.001）。油组的国际骨关节炎研究学会（OARSI）总分也显著更好（p = 0.035）。
关节内注射油有可能在骨关节炎早期保护软骨免于退变。
