Sugimura K, Kimura T, Arakawa H, Ohno T, Wada Y, Kimura Y, Saheki T, Azuma I
Institute of Immunological Science, Hokkaido University, Sapporo, Japan.
Leuk Res. 1990;14(10):931-4. doi: 10.1016/0145-2126(90)90184-b.
Argininosuccinate synthetase (ASS) is a ATP-dependent and rate-limiting enzyme of the urea cycle which catalyzes L-citrulline to L-arginine in combination with argininosuccinate lyase (ASL). We demonstrate here that (a) human normal T and B lymphocytes did not express ASS activity, (b) however, three adult T leukemia (ATL) cell lines tested here exhibited significant elevation of ASS activity, and (c) ASL activity remained relatively constant in normal lymphocytes and various leukemia cell lines. These results suggest that the ASS expression of peripheral blood lymphocytes is of value as a diagnostic marker of leukemia including ATL. The implication of these results is discussed.
精氨琥珀酸合成酶（ASS）是尿素循环中一种依赖ATP的限速酶，它与精氨琥珀酸裂解酶（ASL）共同催化L-瓜氨酸生成L-精氨酸。我们在此证明：（a）人类正常T淋巴细胞和B淋巴细胞不表达ASS活性；（b）然而，在此检测的三种成人T细胞白血病（ATL）细胞系表现出ASS活性显著升高；（c）ASL活性在正常淋巴细胞和各种白血病细胞系中保持相对恒定。这些结果表明，外周血淋巴细胞的ASS表达作为包括ATL在内的白血病的诊断标志物具有价值。本文讨论了这些结果的意义。
