Flock A, Cheung H, Wersäll J
Adv Otorhinolaryngol. 1979;25:12-6. doi: 10.1159/000402911.
Vestibular type 1 hair cells in the waltzing guinea pig contain needle-shaped inclusion bodies which grow in an uncontrolled fashion associated with the destruction of the cell. The needles are shown to be composed by filaments of actin, a protein identified in the electron microscope by its ability to bind subfragment 1 of myosin. Whereas actin filaments in stereocilia are oriented down towards the cell body, filaments in the needles point up towards the cuticular plate. The hereditary lesion appears to be associated with a defective control of polymerization of actin into filaments.
华尔兹豚鼠的前庭1型毛细胞含有针状包涵体，这些包涵体以不受控制的方式生长，并与细胞破坏相关。这些针状物显示由肌动蛋白丝组成，肌动蛋白是一种在电子显微镜下通过其结合肌球蛋白亚片段1的能力而鉴定的蛋白质。虽然静纤毛中的肌动蛋白丝向下朝向细胞体定向，但针状物中的丝向上朝向角质板。这种遗传性病变似乎与肌动蛋白聚合成丝的控制缺陷有关。
