Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany.
Cytokine Growth Factor Rev. 2012 Jun;23(3):85-97. doi: 10.1016/j.cytogfr.2012.04.001. Epub 2012 May 15.
Interleukin (IL)-6-type cytokines are critically involved in health and disease. The duration and strength of IL-6-type cytokine-mediated signaling is tightly regulated to avoid overshooting activities. Here, molecular mechanisms of inter-familiar cytokine cross-talk are reviewed which regulate dynamics and strength of IL-6 signal transduction. Both plasticity and cytokine cross-talk are significantly involved in pro- and anti-inflammatory/regenerative properties of IL-6-type cytokines. Furthermore, we focus on IL-6-type cytokine/cytokine receptor plasticity and cross-talk exemplified by the recently identified composite cytokines IL-30/IL-6R and IL-35, the first inter-familiar IL-6/IL-12 family member. The complete understanding of the intra- and extracellular cytokine networks will aid to develop novel tailor-made therapeutic strategies with reduced side effects.
白细胞介素 (IL)-6 型细胞因子在健康和疾病中起着至关重要的作用。为了避免活动过度，IL-6 型细胞因子介导的信号的持续时间和强度受到严格调节。本文综述了家族间细胞因子相互作用的分子机制，这些机制调节了 IL-6 信号转导的动力学和强度。细胞因子的可塑性和相互作用都显著参与了 IL-6 型细胞因子的促炎/抗炎和再生特性。此外，我们还关注了 IL-6 型细胞因子/细胞因子受体的可塑性和相互作用，以最近发现的复合细胞因子 IL-30/IL-6R 和 IL-35 为例，这是第一个家族间的 IL-6/IL-12 家族成员。深入了解细胞内和细胞外细胞因子网络将有助于开发副作用更小的新型定制治疗策略。
