Lyng R D
Department of Biological Sciences, Indiana University-Purdue University, Ft. Wayne 46805.
Toxicol Lett. 1990 Dec;54(2-3):245-51. doi: 10.1016/0378-4274(90)90191-n.
Several developmental processes interact to convert an epithelial bud into a gland with many lobes. For each chemical tested, 20 glands were placed into a control and each of 3 concentrations of the chemical. From dose-response curves, the concentration that reduced gland growth by 50% was determined and divided into the LD50 for mice. These ratios were used to compare the toxicity of the chemicals. The ratios of cyclamate, diphenhydramine, allopurinol, nitrofen and urethane would indicate that embryotoxicity would not be expected without maternal toxicity. Promethazine, diethyldithiocarbamate, and 5-fluorouracil would be expected to show embryotoxicity without maternal toxicity.
几个发育过程相互作用，将上皮芽转化为具有多个叶的腺体。对于每种测试的化学物质，将20个腺体分别置于对照组以及该化学物质的3种浓度组中。根据剂量反应曲线，确定使腺体生长减少50%的浓度，并将其除以小鼠的半数致死剂量（LD50）。这些比值用于比较化学物质的毒性。甜蜜素、苯海拉明、别嘌醇、除草醚和氨基甲酸乙酯的比值表明，若无母体毒性，则预计不会出现胚胎毒性。异丙嗪、二乙基二硫代氨基甲酸盐和5-氟尿嘧啶预计会在无母体毒性的情况下表现出胚胎毒性。
