al-Attas O S, Laajam M A, Khan M S, al-Drees A Z
Dept. of Biochemistry, College of Science, King Saudi University, Saudi Arabia.
Trop Geogr Med. 1990 Apr;42(2):140-5.
Metabolic indices were assessed in 217 Saudi diabetic patients and 57 control subjects in relation to Body Mass Index (BMI). Patients with BMI values greater than or equal to 27 in male and greater than or equal to 25 in female were considered obese. Obesity was found more frequent in females (82.7%) than in males (40.9%) (p less than 0.01). Basal glucose and HbA1C levels were lower in obese males than in females. C-peptide levels were higher (p less than 0.01) in the obese subjects than in the non-obese. Within the obese group c-peptide levels were higher in males than in females. Triglycerides and total lipids were also higher in the obese group. Our result suggests that a varying degree of obesity influences the rate of both beta cell secretion, insulin resistance and impaired lipid metabolism.
对217名沙特糖尿病患者和57名对照受试者的代谢指标与体重指数（BMI）进行了评估。男性BMI值大于或等于27且女性BMI值大于或等于25的患者被视为肥胖。发现肥胖在女性（82.7%）中比在男性（40.9%）中更常见（p小于0.01）。肥胖男性的基础血糖和糖化血红蛋白（HbA1C）水平低于女性。肥胖受试者的C肽水平高于非肥胖受试者（p小于0.01）。在肥胖组中，男性的C肽水平高于女性。肥胖组中的甘油三酯和总脂质也更高。我们的结果表明，不同程度的肥胖会影响β细胞分泌率、胰岛素抵抗和脂质代谢受损。
