Brereton Andrew Stewart, El Teraifi Hassan
Medical Assessment Unit, Eastbourne DGH, Eastbourne, UK.
BMJ Case Rep. 2012 Apr 2;2012:bcr1220115471. doi: 10.1136/bcr.12.2011.5471.
Mycobacterium malmoense is recognised as an environmental pathogen predominantly affecting populations in Northern Europe. In immuno-competent individuals, isolated pulmonary disease remains the commonest presentation. The authors report a rare case describing a mycotic popliteal aneurysm caused by M malmoense in a 74-year-old man from Hastings, UK with co-existing pulmonary M malmoense disease. Primary pulmonary disease was confirmed by a combination of history, examination and positive radiological and microbiological findings. Tissue analysis of the aneurysm wall during popliteal aneurysm repair confirmed the presence of disseminated M malmoense. Histological analysis of the aneurysm wall showed non-caseating granulomata. The patient completed a 2 year course of rifampicin, ethambutol and clarithromycin which eradicated the organism from his sputum. Further progress has been complicated by the development of an aspergilloma at the site of his eradicated pulmonary M malmoense disease and the need for angioplasty to his bypass grafts 1 year postsurgery.
马尔默分枝杆菌被认为是一种主要影响北欧人群的环境病原体。在免疫功能正常的个体中,孤立性肺部疾病仍然是最常见的表现形式。作者报告了一例罕见病例,描述了一名来自英国黑斯廷斯的74岁男性因马尔默分枝杆菌导致的霉菌性腘动脉瘤,同时患有肺部马尔默分枝杆菌病。通过病史、检查以及阳性的影像学和微生物学检查结果相结合,确诊了原发性肺部疾病。在腘动脉瘤修复过程中对动脉瘤壁进行组织分析,证实存在播散性马尔默分枝杆菌。动脉瘤壁的组织学分析显示为非干酪样肉芽肿。患者完成了为期2年的利福平、乙胺丁醇和克拉霉素疗程,痰中该病原体被清除。进一步的病情发展因在已治愈的肺部马尔默分枝杆菌病部位出现曲菌球以及术后1年对其旁路移植物进行血管成形术的必要性而变得复杂。