Ricketts Reva, Tamboli Pheroze, Czerniak Bogdan, Guo Charles C
Department of Pathology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA.
Arch Pathol Lab Med. 2008 Jun;132(6):1016-20. doi: 10.5858/2008-132-1016-TMROCO.
Tumor-to-tumor metastasis is a rare phenomenon. Renal cell carcinoma is the most common recipient of tumor-to-tumor metastasis in malignant tumors. However, renal angiomyolipoma has not been reported to be a recipient. Here we report 2 cases of tumor-to-tumor metastasis to renal angiomyolipoma. In one case, the donor tumor originated from neuroendocrine carcinoma of the pancreas, and in the other case the donor tumor was from adenocarcinoma of the lung. The donor tumors showed morphologic features that did not easily fit into renal angiomyolipoma, and they also demonstrated patterns of immunoreactivity consistent with the primary tumors rather than with renal angiomyolipoma. To our knowledge, these are the first reported cases of tumor-to-tumor metastasis to renal angiomyolipoma. An awareness of this phenomenon is important to avoid an incorrect diagnosis when encountering unusual morphologic features in renal angiomyolipoma.
肿瘤转移至肿瘤是一种罕见现象。肾细胞癌是恶性肿瘤中肿瘤转移至肿瘤最常见的接受者。然而，肾血管平滑肌脂肪瘤尚未被报道为接受者。在此，我们报告2例肿瘤转移至肾血管平滑肌脂肪瘤的病例。1例中，供体肿瘤起源于胰腺神经内分泌癌，另1例中供体肿瘤来自肺腺癌。供体肿瘤呈现出不易与肾血管平滑肌脂肪瘤相符的形态学特征，且其免疫反应模式与原发肿瘤一致，而非与肾血管平滑肌脂肪瘤一致。据我们所知，这些是首次报道的肿瘤转移至肾血管平滑肌脂肪瘤的病例。认识到这一现象对于在肾血管平滑肌脂肪瘤出现异常形态学特征时避免误诊很重要。
