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生长激素结合蛋白与多种形式的生长激素:对测量的影响

Growth hormone binding proteins and various forms of growth hormone: implications for measurements.

作者信息

Baumann G

机构信息

Department of Medicine, Northwestern University Medical School, Chicago, Illinois.

出版信息

Acta Paediatr Scand Suppl. 1990;370:72-80; discussion 81. doi: 10.1111/j.1651-2227.1990.tb11677.x.

DOI:10.1111/j.1651-2227.1990.tb11677.x
PMID:2260461
Abstract

GH measurements are complicated by numerous physiologically occurring GH forms, by the lack of availability of completely specific reagents for the various GH isoforms, and by interference of the circulating BP in some assays. The discrepancies between assay results are partly due to these factors, with monoclonal immunoassays or RRAs being more affected than polyclonal immunoassays.

摘要

生长激素(GH)的测量因多种生理存在的GH形式、缺乏针对各种GH异构体的完全特异性试剂以及某些检测中循环结合蛋白(BP)的干扰而变得复杂。检测结果之间的差异部分归因于这些因素,单克隆免疫测定或放射受体测定(RRAs)比多克隆免疫测定受影响更大。

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