Ranno Stefano, Sacchi Matteo, Brancato Cinzia, Gilardi Daniela, Lembo Andrea, Nucci Paolo
Eye Clinic, San Giuseppe Hospital, University of Milan, Via San Vittore 12, Milan, Italy.
ScientificWorldJournal. 2012;2012:804730. doi: 10.1100/2012/804730. Epub 2012 Apr 19.
To compare the ocular hypotensive effect of tafluprost with prostaglandin analogues (PGAs) in glaucoma patients.
89 primary open-angle glaucoma patients treated with bimatoprost, latanoprost, or travoprost for at least 3 months complaining for ocular discomfort were switched to tafluprost. IOP was assessed at baseline and 3 months after switching the therapy by daily curve. Primary outcome was to compare the mean daily IOP of tafluprost with PGAs.
The mean daily IOP was 16 ± 2.1 and 16.6 ± 2.0 mm Hg at baseline and after switching to tafluprost, respectively (P > 0.05). When analysis was carried out between tafluprost and each previous PGAs, the comparison between latanoprost and tafluprost and travoprost and tafluprost did not show any statistically significant difference in mean daily IOP and at each time point. The comparison between bimatoprost and tafluprost showed a statistically significant difference in mean daily IOP (P < 0.05) and at each time point (P < 0.05).
After 3 months of switching tafluprost showed an overall IOP lowering effect similar to others PGAs. When each PGA was compared with tafluprost, bimatoprost showed to provide a statistically significant additional IOP lowering effect.
比较他氟前列素与前列腺素类似物（PGAs）在青光眼患者中的降眼压效果。
89例接受比马前列素、拉坦前列素或曲伏前列素治疗至少3个月且抱怨眼部不适的原发性开角型青光眼患者改用他氟前列素。在基线期以及换药3个月后通过每日眼压曲线评估眼压。主要结局是比较他氟前列素与PGAs的平均每日眼压。
基线期和改用他氟前列素后，平均每日眼压分别为16±2.1和16.6±2.0 mmHg（P>0.05）。当对他氟前列素与每种先前使用的PGAs进行分析时，拉坦前列素与他氟前列素之间以及曲伏前列素与他氟前列素之间在平均每日眼压及各个时间点的比较均未显示出任何统计学上的显著差异。比马前列素与他氟前列素之间的比较在平均每日眼压方面（P<0.05）以及各个时间点（P<0.05）均显示出统计学上的显著差异。
改用他氟前列素3个月后，其总体降眼压效果与其他PGAs相似。当将每种PGAs与他氟前列素进行比较时，比马前列素显示出具有统计学意义的额外降眼压效果。
