Indian Institute of Technology, Kharagpur, Kharagpur 721302, India.
J Anal Methods Chem. 2012;2012:109058. doi: 10.1155/2012/109058. Epub 2012 Mar 26.
Serially diluted and agitated (SAD) drugs available commercially are in use with great faith because of the astonishing results they produce. The scientific viewpoint attached to the centuries-old therapy with SAD drugs, as in homeopathy, remained doubtful for want of appropriate research and insufficient evidence base. The conflicting points related to SAD drug mostly related to the level of concentrations/dilutions, use of drug in contradictory clinical conditions compared to the modern system of medicine, identification of medicinally active ingredient in concentrations and dilutions used in commercially available SAD drugs, and lack of laboratory-based pharmacological data vis-à-vis modern medicine. Modus operandi of SAD drug is also unknown. To address some of these issues an analytical study was carried out wherein commercially available SAD drug Digitalis purpurea, commonly used in different systems of medicine, was put to test. Various concentrations of commercially available Digitalis purpurea were analyzed using analytical methods: cyclic voltammetry, emission spectroscopy, and UV-VIS spectroscopy. These analytical methods apparently identified the medicinal ingredients and effect of serial dilution in commercial preparation of the drugs.
市售的连续稀释和搅拌（SAD）药物因其惊人的效果而被广泛使用，深受信赖。由于缺乏适当的研究和证据基础，SAD 药物与几个世纪以来的顺势疗法等疗法相关的科学观点仍然存在疑问。与 SAD 药物相关的主要争议点涉及浓度/稀释度水平、与现代医学相比在矛盾的临床条件下使用药物、在商业上可获得的 SAD 药物中使用的浓度和稀释度中鉴定药用活性成分，以及缺乏实验室为基础的药理学数据与现代医学相比。SAD 药物的作用方式也不清楚。为了解决其中的一些问题，进行了一项分析性研究，对不同医学体系中常用的市售 SAD 药物洋地黄进行了测试。使用分析方法：循环伏安法、发射光谱法和紫外可见光谱法对市售的洋地黄进行了各种浓度的分析。这些分析方法显然确定了药用成分和商业制剂中连续稀释的效果。
