Department of Pediatrics, Tampere University Hospital, Institute of Biomedical Technology and BioMediTech, University of Tampere, Finland.
Acta Paediatr. 2012 Sep;101(9):900-5. doi: 10.1111/j.1651-2227.2012.02740.x. Epub 2012 Jun 12.
In 2011, the Nobel Prize in Physiology and Medicine was rewarded, in part, for research on the Drosophila immune response. The research described the role of the Drosophila Toll receptor in antifungal resistance, and the subsequent characterization of Toll-like receptors in mammals reshaped our understanding of the immune system. This review summarizes the potential of the Drosophila model and describes the path that has lead Drosophila to become an important model to study immunity.
Drosophila melanogaster has been one of the most fruitful models to study innate immunity.
2011 年，诺贝尔生理学或医学奖部分授予了对果蝇免疫反应的研究。该研究描述了果蝇 Toll 受体在抗真菌中的作用，随后在哺乳动物中鉴定 Toll 样受体，这改变了我们对免疫系统的理解。这篇综述总结了果蝇模型的潜力，并描述了使 Drosophila 成为研究免疫的重要模型的途径。
黑腹果蝇一直是研究先天免疫的最有成效的模型之一。
