Abnave Prasad, Conti Filippo, Torre Cedric, Ghigo Eric
CNRS UMR 7278, URMITE, IRD198, INSERM U1095, Aix-Marseille Université Marseille, France.
Front Cell Infect Microbiol. 2015 Jan 12;4:184. doi: 10.3389/fcimb.2014.00184. eCollection 2014.
The strategies evolved by pathogens to infect hosts and the mechanisms used by the host to eliminate intruders are highly complex. Because several biological pathways and processes are conserved across model organisms, these organisms have been used for many years to elucidate and understand the mechanisms of the host-pathogen relationship and particularly to unravel the molecular processes enacted by the host to kill pathogens. The emergence of RNA interference (RNAi) and the ability to apply it toward studies in model organisms have allowed a breakthrough in the elucidation of host-pathogen interactions. The aim of this mini-review is to highlight and describe recent breakthroughs in the field of host-pathogen interactions using RNAi screens of model organisms. We will focus specifically on the model organisms Drosophila melanogaster, Caenorhabditis elegans, and Danio rerio. Moreover, a recent study examining the immune system of planarian will be discussed.
病原体用来感染宿主的策略以及宿主用来清除入侵者的机制非常复杂。由于多种生物途径和过程在模式生物中是保守的，这些生物多年来一直被用于阐明和理解宿主 - 病原体关系的机制，特别是用于揭示宿主杀死病原体所采取的分子过程。RNA干扰（RNAi）的出现以及将其应用于模式生物研究的能力，使得在阐明宿主 - 病原体相互作用方面取得了突破。本综述的目的是突出并描述使用模式生物的RNAi筛选在宿主 - 病原体相互作用领域的最新突破。我们将特别关注模式生物黑腹果蝇、秀丽隐杆线虫和斑马鱼。此外，还将讨论最近一项关于涡虫免疫系统的研究。
