中性粒细胞在缺血再灌注后会聚集并导致骨骼肌功能障碍。
Neutrophils accumulate and contribute to skeletal muscle dysfunction after ischemia-reperfusion.
作者信息
Walden D L, McCutchan H J, Enquist E G, Schwappach J R, Shanley P F, Reiss O K, Terada L S, Leff J A, Repine J E
机构信息
Webb-Waring Lung Institute, University of Colorado Health Science Center, Denver 80262.
出版信息
Am J Physiol. 1990 Dec;259(6 Pt 2):H1809-12. doi: 10.1152/ajpheart.1990.259.6.H1809.
Skeletal muscles subjected to ischemia and then reperfusion develop contractile dysfunction for reasons that are unclear. We found that rats pretreated with vinblastine 4 days before study had decreased numbers of blood neutrophils and increased gastrocnemius muscle function after ischemia (3h) and reperfusion (4 h) compared with untreated rats or rats treated 4 days before study with saline. By comparison, rats pretreated with vinblastine or saline 1 day before study had increased blood neutrophils and decreased gastrocnemius muscle contractile function after ischemia-reperfusion compared with untreated rats. In addition, numbers of neutrophils in gastrocnemius muscles paralleled numbers of blood neutrophils and correlated with gastrocnemius muscle edema and contractile function after ischemia and reperfusion. The results indicate that neutrophils accumulate and may play an important role in the genesis of skeletal muscle contractile dysfunction after ischemia-reperfusion.
遭受缺血再灌注的骨骼肌会出现收缩功能障碍，其原因尚不清楚。我们发现，在研究前4天用长春碱预处理的大鼠，与未处理的大鼠或在研究前4天用生理盐水处理的大鼠相比，缺血（3小时）和再灌注（4小时）后血液中性粒细胞数量减少，腓肠肌功能增强。相比之下，在研究前1天用长春碱或生理盐水预处理的大鼠，与未处理的大鼠相比，缺血再灌注后血液中性粒细胞增多，腓肠肌收缩功能降低。此外，腓肠肌中的中性粒细胞数量与血液中性粒细胞数量平行，并与缺血再灌注后腓肠肌水肿和收缩功能相关。结果表明，中性粒细胞积聚可能在缺血再灌注后骨骼肌收缩功能障碍的发生中起重要作用。
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