Department of Biomedical Engineering, Parks College of Engineering, Aviation, and Technology, Saint Louis University, 3507 Lindell Blvd, St. Louis, MO 63103, USA.
Department of Biology, Saint Louis University, St. Louis, MO 63103, USA.
Int J Mol Sci. 2021 Mar 23;22(6):3265. doi: 10.3390/ijms22063265.
Skeletal muscle regeneration is highly dependent on the inflammatory response. A wide variety of innate and adaptive immune cells orchestrate the complex process of muscle repair. This review provides information about the various types of immune cells and biomolecules that have been shown to mediate muscle regeneration following injury and degenerative diseases. Recently developed cell and drug-based immunomodulatory strategies are highlighted. An improved understanding of the immune response to injured and diseased skeletal muscle will be essential for the development of therapeutic strategies.
骨骼肌再生高度依赖于炎症反应。多种先天和适应性免疫细胞共同调控肌肉修复的复杂过程。本综述提供了有关各种类型的免疫细胞和生物分子的信息，这些细胞和生物分子已被证明可介导损伤和退行性疾病后的肌肉再生。重点介绍了最近开发的基于细胞和药物的免疫调节策略。深入了解受损和患病骨骼肌的免疫反应对于治疗策略的发展至关重要。
