Newby F D, DiGirolamo M, Cotsonis G A, Kutner M H
Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30303.
Am J Physiol. 1990 Dec;259(6 Pt 2):R1117-25. doi: 10.1152/ajpregu.1990.259.6.R1117.
We analyzed retrospectively data from 148 chow-fed male Wistar rats killed between the age of 6 wk and 2 yr while varying in body weight from 136 to 917 g. The purpose of this study was to clarify the relationship of body weight and body lipid content with the composition and cellularity of the epididymal and retroperitoneal fat depots. A positive linear association was found between body weight and body water or fat-free dry residue, whereas total body lipid exhibited a curvilinear relationship with body weight. The weight of the epididymal pads was linearly related to body weight but not to body lipid. In contrast, retroperitoneal pad weight was exponentially related to body weight and paralleled total body lipid. A strong linear correlation was found between total body lipid and weight (r = 0.959) or depot lipid content (r = 0.967) of the retroperitoneal fat pads. In this rat model of aging and spontaneous obesity, significant regional differences exist in adipose depot composition and cellularity. A practical outcome of this study is a simple and accurate prediction of body lipid content from the gravimetric determination of the retroperitoneal fat depots.
我们回顾性分析了148只以普通饲料喂养的雄性Wistar大鼠的数据，这些大鼠在6周龄至2岁之间被处死，体重在136至917克之间。本研究的目的是阐明体重和体脂含量与附睾和腹膜后脂肪库的组成及细胞构成之间的关系。体重与身体水分或无脂干残余物之间呈正线性关联，而总体脂与体重呈曲线关系。附睾脂肪垫的重量与体重呈线性相关，但与体脂无关。相反，腹膜后脂肪垫重量与体重呈指数关系，且与总体脂平行。在总体脂与腹膜后脂肪垫的重量（r = 0.959）或脂肪库脂质含量（r = 0.967）之间发现了很强的线性相关性。在这个衰老和自发性肥胖的大鼠模型中，脂肪库的组成和细胞构成存在显著的区域差异。本研究的一个实际成果是通过对腹膜后脂肪库进行重量测定来简单而准确地预测体脂含量。
