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不同年龄 Wistar 大鼠的代谢综合征标志物。

Metabolic syndrome markers in wistar rats of different ages.

机构信息

Department of Physical Education, São Paulo State University (UNESP - Universidade Estadual Paulista), Rio Claro, SP, Brazil.

出版信息

Diabetol Metab Syndr. 2012 Apr 27;4(1):16. doi: 10.1186/1758-5996-4-16.

DOI:10.1186/1758-5996-4-16
PMID:22541367
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3482597/
Abstract

In recent decades, metabolic syndrome has become a public health problem throughout the world. Longitudinal studies in humans have several limitations due to the invasive nature of certain analyses and the size and randomness of the study populations. Thus, animal models that are able to mimic human physiological responses could aid in investigating metabolic disease. Thus, the present study was designed to analyze metabolic syndrome markers in albino Wistar rats (Rattus norvegicus) of different ages. The following parameters were assessed at two (young), four ( adult), six (adult), and twelve (mature) months of age: glucose tolerance (glucose tolerance test); insulin sensitivity (insulin tolerance test); fasting serum glucose, triglycerides, total cholesterol, HDL cholestero, and LDL cholesterol concentrations; glucose uptake in isolated soleus muscle; and total lipid concentration in subcutaneous, mesenteric, and retroperitoneal adipose tissue. We found that aging triggered signs of metabolic syndrome in Wistar rats. For example, mature rats showed a significant increase in body weight that was associated. In addition, mature rats showed an increase in the serum concentration of triglycerides, total cholesterol, and LDL cholesterol, which is characteristic of dyslipidemia. There was also an increase in serum glucose compared with the younger groups of animals. Therefore, aging Wistar rats appear to be an interesting model to study the changes related to metabolic syndrome.

摘要

近几十年来，代谢综合征已成为全球公共卫生问题。由于某些分析方法的侵入性以及研究人群的规模和随机性，人类的纵向研究存在诸多局限性。因此，能够模拟人类生理反应的动物模型有助于研究代谢性疾病。因此，本研究旨在分析不同年龄的白化 Wistar 大鼠（Rattus norvegicus）的代谢综合征标志物。在 2（年轻）、4（成年）、6（成年）和 12（成熟）个月时评估以下参数：葡萄糖耐量（葡萄糖耐量试验）；胰岛素敏感性（胰岛素耐量试验）；空腹血清葡萄糖、甘油三酯、总胆固醇、HDL 胆固醇和 LDL 胆固醇浓度；分离的比目鱼肌中的葡萄糖摄取量；以及皮下、肠系膜和腹膜后脂肪组织中的总脂质浓度。我们发现，衰老会引发 Wistar 大鼠出现代谢综合征的迹象。例如，成熟大鼠的体重显著增加，这与胰岛素抵抗有关。此外，成熟大鼠的血清甘油三酯、总胆固醇和 LDL 胆固醇浓度升高，这是血脂异常的特征。与年轻动物组相比，血清葡萄糖也有所增加。因此，衰老的 Wistar 大鼠似乎是研究与代谢综合征相关变化的一个有趣模型。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca2b/3482597/10682a95877f/1758-5996-4-16-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca2b/3482597/226f8183c0d6/1758-5996-4-16-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca2b/3482597/5427958960bf/1758-5996-4-16-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca2b/3482597/918f1eba2f72/1758-5996-4-16-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca2b/3482597/10682a95877f/1758-5996-4-16-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca2b/3482597/226f8183c0d6/1758-5996-4-16-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca2b/3482597/5427958960bf/1758-5996-4-16-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca2b/3482597/918f1eba2f72/1758-5996-4-16-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca2b/3482597/10682a95877f/1758-5996-4-16-4.jpg

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