左旋咪唑受体：二次觉醒。
Levamisole receptors: a second awakening.
机构信息
Department of Biomedical Sciences, Iowa State University, Ames, IA 50011-1250, USA.
出版信息
Trends Parasitol. 2012 Jul;28(7):289-96. doi: 10.1016/j.pt.2012.04.003. Epub 2012 May 17.
Abstract
Levamisole and pyrantel are old (1965) but useful anthelmintics that selectively activate nematode acetylcholine ion channel receptors; they are used to treat roundworm infections in humans and animals. Interest in their actions has surged, giving rise to new knowledge and technical advances, including an ability to reconstitute receptors that reveal more details of modes of action/resistance. We now know that the receptors are plastic and may form diverse species-dependent subtypes of receptor with different sensitivities to individual cholinergic anthelmintics. Understanding the biology of the levamisole receptors is expected to inform other studies on anthelmintics (ivermectin and emodepside) that act on ion channels.
摘要
左旋咪唑和噻嘧啶是古老的（1965 年）但有用的驱虫药，它们选择性地激活线虫乙酰胆碱离子通道受体；它们被用于治疗人类和动物的蛔虫感染。人们对它们的作用产生了浓厚的兴趣，从而产生了新的知识和技术进步，包括重新构建受体的能力，这揭示了作用模式/耐药性的更多细节。我们现在知道，这些受体是可塑的，可能形成依赖于物种的不同亚型的受体，对个别胆碱能驱虫药的敏感性不同。了解左旋咪唑受体的生物学有望为其他作用于离子通道的驱虫药（伊维菌素和埃莫迪派德）的研究提供信息。
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