Huttenlocher P R, Hapke R J
Department of Pediatrics, University of Chicago, IL 60637.
Ann Neurol. 1990 Nov;28(5):699-705. doi: 10.1002/ana.410280516.
One hundred forty-five children with seizures that were refractory to medical therapy for at least 2 years were followed 5 to 20 years after onset. The majority of children with uncontrollable seizures (61%) were mentally retarded, and most of these (73%) had onset of seizures at younger than 2 years of age. Age of onset was significantly later (mean 5.0 +/- 0.5 yr [SEM]) in the group of children with borderline to normal intelligence. Follow-up data showed remission of seizures in a significant proportion of children with borderline or normal intelligence, with a linear decrease of the percentage with persistent seizures at a rate of about 4% per year. Remission of seizures was much less frequent (1.5%/yr) in the group with mental retardation. Seizure type had some effects on outcome. Children with focal atrophic brain lesions did no worse than those without definable pathology on brain-imaging studies.
对145名经药物治疗至少2年仍难治性癫痫发作的儿童，在发病后5至20年进行随访。大多数癫痫发作无法控制的儿童（61%）存在智力发育迟缓，其中大多数（73%）在2岁之前就开始发作。在智力临界至正常的儿童组中，发病年龄显著较晚（平均5.0 +/- 0.5岁[标准误]）。随访数据显示，相当一部分智力临界或正常的儿童癫痫发作得到缓解，持续性癫痫发作儿童的百分比以每年约4%的速度呈线性下降。智力发育迟缓组癫痫发作缓解的频率要低得多（每年1.5%）。癫痫发作类型对预后有一定影响。在脑成像研究中，有局灶性脑萎缩病变的儿童与无明确病理改变的儿童预后相当。
