Department of Nutrition, Food Science, Physiology and Toxicology, University of Navarra, Pamplona, Spain.
J Pediatr. 2012 Sep;161(3):466-470.e2. doi: 10.1016/j.jpeds.2012.04.004. Epub 2012 May 18.
To estimate the contribution of 9 obesity-related polymorphisms and a genetic predisposition score (GPS) on anthropometric and biochemical variables before and after a weight loss intervention program in overweight/obese Spanish adolescents.
Overweight/obese adolescents (n = 168; 12-16 years) participating in the EVASYON program were genotyped for 9 obesity-related single nucleotide polymorphisms in the FTO, MC4R, TMEM18, IL6, PPARG, and ADIPQ genes.
At baseline, the GPS showed a significant association with body mass index-standard deviation score (BMI-SDS) and fat mass. After 3 months of intervention, this GPS also showed a relationship with the variation of both anthropometric measurements. After adjusting for baseline BMI-SDS, subjects with a lower GPS had a greater improvement on metabolic profile, as well as a better response to physical activity, compared with those subjects with a higher GPS.
The GPS seems to have an important relationship with BMI-SDS and fat mass both at baseline and after a 3-month weight loss lifestyle intervention. Obese and overweight adolescents with a lower GPS have a greater benefit of weight loss after 3 months of a multidisciplinary lifestyle intervention.
评估 9 种肥胖相关的多态性和遗传易感性评分（GPS）对超重/肥胖西班牙青少年减肥干预前后人体测量和生化指标的影响。
参加 EVASYON 计划的超重/肥胖青少年（n=168；12-16 岁）进行了 9 种肥胖相关单核苷酸多态性（FTO、MC4R、TMEM18、IL6、PPARG 和 ADIPQ 基因）的基因分型。
基线时，GPS 与体重指数标准差评分（BMI-SDS）和体脂呈显著相关。干预 3 个月后，GPS 也与这两种人体测量指标的变化有关。在校正基线 BMI-SDS 后，GPS 较低的受试者在代谢谱方面的改善更大，对体育活动的反应也更好，而 GPS 较高的受试者则不然。
GPS 似乎与基线时和 3 个月减肥生活方式干预后的 BMI-SDS 和体脂有重要关系。在进行 3 个月的多学科生活方式干预后，GPS 较低的肥胖和超重青少年体重减轻的获益更大。
