3rd Department of Medicine, 1st Faculty of Medicine of Charles University and General University Hospital in Prague, Prague, Czech Republic.
Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
Med Sci Monit. 2018 Oct 20;24:7493-7498. doi: 10.12659/MSM.907180.
BACKGROUND This study was carried out to determine the relationship between the common TMEM-18 (rs4854344, G>T) and NYD-SP18 (rs6971091, G>A) gene variants and weight loss after lifestyle interventions (increased physical activity in conjunction with optimal dietary intake) in overweight/obese children/adolescents. MATERIAL AND METHODS We genotyped 684 unrelated, white, non-diabetic children (age 12.7±2.1 years, average BMI at baseline 30.66±4.80 kg/m²). Anthropometric and biochemical examinations were performed before and after 4 weeks of an intensive lifestyle intervention. RESULTS The mean weight loss achieved was 5.20±2.02 kg (P<0.001). NYDSP-18 AA homozygotes had significantly higher abdominal skinfold value before and after the intervention (both, P=0.001). No significant associations between BMI decrease and the NYD-SP18 and TMEM18 variants were found. Associations between all anthropometrical and biochemical changes and genes remained non-significant after data were adjusted for sex, age, and baseline values. CONCLUSIONS Decreased body weight in overweight/obese children is not significantly influenced by the NYD-SP18 rs6971091 or TMEM18 rs4854344 polymorphisms.
背景 本研究旨在确定 TMEM-18（rs4854344，G>T）和 NYD-SP18（rs6971091，G>A）基因变异与超重/肥胖儿童/青少年生活方式干预（增加体力活动与最佳饮食摄入相结合）后体重减轻之间的关系。 材料与方法 我们对 684 名无关的白种、非糖尿病儿童（年龄 12.7±2.1 岁，基线平均 BMI 为 30.66±4.80 kg/m²）进行了基因分型。在强化生活方式干预 4 周前后进行了人体测量和生化检查。 结果 平均体重减轻 5.20±2.02 kg（P<0.001）。NYDSP-18 AA 纯合子在干预前后的腹部皮褶厚度值显著更高（均 P=0.001）。BMI 下降与 NYD-SP18 和 TMEM18 变异体之间无显著相关性。在调整性别、年龄和基线值后，所有人体测量和生化变化与基因之间的关联仍然不显著。 结论 超重/肥胖儿童的体重减轻与 NYD-SP18 rs6971091 或 TMEM18 rs4854344 多态性无显著相关性。
