Ruiz-Esquide Virginia, Sanmartí Raimon
Unidad de Artritis, Servicio de Reumatologia, Hospital Clínic de Barcelona, Barcelona, España.
Reumatol Clin. 2012 Nov-Dec;8(6):342-50. doi: 10.1016/j.reuma.2012.02.011. Epub 2012 May 17.
Many environmental factors have been associated with an increased risk of developing Rheumatoid Arthritis (RA), but so far smoking is the only environmental risk factor that has been extensively studied and widely accepted. Smoking is associated with an increased risk of developing seropositive RA (RF and/or ACPA). Recent studies show that tobacco smoking can influence disease phenotype, with the development of more aggressive disease and greater joint damage; but other studies show contradictory results. Recent data suggests that response to antirheumatic therapy in RA is worse in smokers. In this article we review different environmental factors that have been associated with an increased risk of developing RA, with a special interest in tobacco smoking.
许多环境因素都与类风湿关节炎（RA）发病风险增加有关，但迄今为止，吸烟是唯一经过广泛研究并被广泛认可的环境风险因素。吸烟与血清阳性RA（类风湿因子和/或抗环瓜氨酸肽抗体）发病风险增加有关。最近的研究表明，吸烟会影响疾病表型，导致病情更具侵袭性且关节损伤更严重；但其他研究结果却相互矛盾。最新数据表明，吸烟者对RA抗风湿治疗的反应较差。在本文中，我们综述了与RA发病风险增加相关的不同环境因素，尤其关注吸烟。
