Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow Biomedical Research Centre, 120 University Place, Glasgow G12 8TA, UK.
Trends Immunol. 2012 Aug;33(8):389-96. doi: 10.1016/j.it.2012.04.005. Epub 2012 May 19.
Interleukin (IL)-33 is a member of the IL-1 cytokine family that has been shown to play an important role in the induction and effector phases of type 2 immune responses. Both innate and adaptive immunity are regulated by IL-33, and many studies have shown disease-associated functions for this cytokine. Recently, IL-33 has been implicated in the function of novel innate lymphocyte populations that regulate both protective responses in parasitic infections and allergic airway inflammation. Here, we discuss recent data highlighting the dual roles of IL-33 in protective and deleterious immune responses.
白细胞介素 (IL)-33 是 IL-1 细胞因子家族的一员，它在 2 型免疫反应的诱导和效应阶段发挥着重要作用。IL-33 调节先天免疫和适应性免疫，许多研究表明该细胞因子与疾病相关功能有关。最近，IL-33 被牵连到新型先天淋巴细胞群的功能中，这些细胞群调节寄生虫感染中的保护性反应和过敏性气道炎症。在这里，我们讨论了最近的数据，这些数据强调了 IL-33 在保护性和有害免疫反应中的双重作用。
