Division of Infection and Immunity, The School of Medicine, Systems Immunity University Research Institute, College of Biomedical and Life Sciences, Cardiff University, Cardiff, Wales, UK.
Clin Exp Immunol. 2018 Jul;193(1):37-46. doi: 10.1111/cei.13116. Epub 2018 Mar 9.
The cytokine interleukin (IL)-6 is a major therapeutic target for the treatment of various inflammatory and autoimmune diseases. While IL-6 receives considerable attention in studies of innate and adaptive immunity, the IL-6-related family member IL-27 is recognized increasingly for its effects on cellular proliferation, differentiation and leucocyte effector functions. Both cytokines activate responses in myeloid and stromal tissue cells, where they direct the transition from innate to adaptive immunity. However, they are identified frequently as lymphokines that control responses in T cells and B cells. In this regard, IL-27 often opposes the action of IL-6. Here, we will review the role of IL-6 and IL-27 in inflammation, with a particular focus on inflammatory arthritis, and discuss their importance in the diagnosis, stratification and treatment of autoimmune disease.
细胞因子白细胞介素（IL）-6 是治疗各种炎症和自身免疫性疾病的主要治疗靶点。虽然 IL-6 在先天和适应性免疫研究中受到广泛关注，但 IL-6 相关家族成员 IL-27 因其对细胞增殖、分化和白细胞效应功能的影响而越来越受到重视。这两种细胞因子均可激活骨髓和基质组织细胞的反应，从而引导从先天免疫到适应性免疫的转变。然而，它们常被鉴定为控制 T 细胞和 B 细胞反应的淋巴因子。在这方面，IL-27 通常与 IL-6 的作用相反。在这里，我们将回顾 IL-6 和 IL-27 在炎症中的作用，特别关注炎症性关节炎，并讨论它们在自身免疫性疾病的诊断、分层和治疗中的重要性。
