Department of Hypertension, Chair of Nephrology and Hypertension, Medical University of Lodz, Poland.
Prog Lipid Res. 2012 Oct;51(4):314-24. doi: 10.1016/j.plipres.2012.03.003. Epub 2012 May 15.
High density lipoprotein (HDL) has many properties, which contribute to its atheroprotective role. However, some recent clinical trials have identified subjects with the progression of atherosclerosis despite normal levels of HDL cholesterol. This raises the question if all subfractions of HDL have the same properties. Moreover, recent investigations have shown that both acute and chronic inflammation may lead to structural and functional changes of HDL, which render the particles proinflammatory. Although therapeutic agents that increase HDL levels are now quite well established it is not clear whether they influence HDL quality. We review the current state of knowledge on the properties of HDL and factors/therapeutic agents which may restrain the transformation of normal HDL into dysfunctional HDL.
高密度脂蛋白（HDL）具有多种特性，有助于其发挥抗动脉粥样硬化作用。然而，一些最近的临床试验发现，尽管 HDL 胆固醇水平正常，但仍有一些患者的动脉粥样硬化进展。这就提出了一个问题，即 HDL 的所有亚组分是否具有相同的特性。此外，最近的研究表明，急性和慢性炎症都可能导致 HDL 的结构和功能发生变化，从而使这些颗粒具有促炎作用。虽然目前已经有很多方法可以增加 HDL 水平，但尚不清楚它们是否会影响 HDL 的质量。我们回顾了有关 HDL 特性以及可能抑制正常 HDL 转化为功能失调的 HDL 的因素/治疗药物的最新知识状态。
