Division of Endocrinology and Metabolism, Department of Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
Clin Chim Acta. 2012 Oct 9;413(19-20):1647-51. doi: 10.1016/j.cca.2012.05.008. Epub 2012 May 15.
Monocyte chemoattractant protein-1 (MCP-1) is a vital inflammatory marker of obesity. Whether obesity by itself increases the risk of chronic kidney injury and accelerates its progression is unknown. More importantly, it is unknown whether obesity could induce kidney injury by MCP-1.
We enrolled 40 obese men and 26 healthy volunteers who served as controls. The degree of insulin resistance was evaluated by the homeostasis model assessment (HOMA-IR) method, and kidney function was determined based on the estimated glomerular filtration rate (eGFR), albuminuria, the concentration of serum cystatin C (S-CysC), and the urinary cystatin C to creatinine ratio (UCCR).
The obese subjects had significantly higher S-CysC concentration (1114±288 vs.962±169 mg/L, p=0.021) and a higher UCCR (3.5±1.6 vs. 2.5±0.8 μg/g, p=0.002) than those of controls. The concentration of circulating MCP-1 and the urinary MCP-1 to creatinine ratio (UMCR) were higher in the obese group and were correlated with fat mass and HOMA-IR. Using stepwise multiple linear regression analysis, circulating MCP-1 concentration was found to be independently associated with the amount of S-CysC. In addition, the UMCR was independently associated with the UCCR.
The concentrations of circulating and urinary monocyte chemoattractant protein-1 are associated with chronic renal injury in obese men.
单核细胞趋化蛋白-1（MCP-1）是肥胖的重要炎症标志物。肥胖本身是否会增加慢性肾损伤的风险并加速其进展尚不清楚。更重要的是，肥胖是否可以通过 MCP-1 诱导肾损伤尚不清楚。
我们招募了 40 名肥胖男性和 26 名健康志愿者作为对照组。胰岛素抵抗程度通过稳态模型评估（HOMA-IR）方法进行评估，并且根据估计肾小球滤过率（eGFR）、蛋白尿、血清胱抑素 C（S-CysC）浓度和尿胱抑素 C 与肌酐比（UCCR）来确定肾功能。
肥胖组的 S-CysC 浓度（1114±288 比 962±169mg/L，p=0.021）和 UCCR（3.5±1.6 比 2.5±0.8μg/g，p=0.002）明显高于对照组。循环 MCP-1 和尿 MCP-1 与肌酐比（UMCR）在肥胖组中更高，与脂肪量和 HOMA-IR 相关。使用逐步多元线性回归分析，发现循环 MCP-1 浓度与 S-CysC 的量独立相关。此外，UMCR 与 UCCR 独立相关。
循环和尿单核细胞趋化蛋白-1 的浓度与肥胖男性的慢性肾损伤有关。
