Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1, Ogawahigashi, Kodaira, Tokyo, 187-8502, Japan.
Prog Neuropsychopharmacol Biol Psychiatry. 2012 Aug 7;38(2):341-4. doi: 10.1016/j.pnpbp.2012.05.007. Epub 2012 May 17.
The β3-adrenoceptor (ADRB3) gene Trp64Arg polymorphism has been shown to be associated with obesity as well as type 2 diabetes and cardiovascular disease. The incidence of overweight and the risks of type 2 diabetes and cardiovascular disease are also increased in major depression and schizophrenia. We hypothesized that the Trp64Arg polymorphism may be associated with increased risk of schizophrenia and depression.
The Trp64Arg was genotyped in 504 patients with schizophrenia, 650 with major depressive disorder (MDD), and 1170 healthy controls. Of these participants, body mass index (BMI) data were available for 125 patients with schizophrenia, 219 with MDD, and 261 controls.
No significant difference in genotype or allele distribution was found across the diagnostic groups. No significant difference in BMI was observed between the Arg allele carriers and the non-carriers in the MDD and the control groups. However, patients with schizophrenia carrying the Arg allele had significantly higher BMI (Mean (SD): Arg carriers: 26.5 (6.9), Arg non-carriers: 23.8 (4.3); P=0.019) and a higher rate of being overweight (BMI of 25 or more) compared to their counterparts (Trp/Trp group) (% overweight (SE): Arg carriers: 52.3 (7.5), Arg non-carriers: 32.1 (5.2); P=0.027).
We obtained no evidence for the association of ADRB3 Trp64Arg with the development of MDD or schizophrenia. However, the Arg allele was found to be associated with higher BMI and being overweight in patients with schizophrenia. This may imply that genotyping ADRB3 is of clinical use to detect schizophrenic individuals at risk for developing obesity.
β3-肾上腺素能受体（ADRB3）基因 Trp64Arg 多态性与肥胖以及 2 型糖尿病和心血管疾病有关。超重的发生率以及 2 型糖尿病和心血管疾病的风险在重度抑郁症和精神分裂症中也会增加。我们假设 Trp64Arg 多态性可能与精神分裂症和抑郁症的风险增加有关。
对 504 例精神分裂症患者、650 例重度抑郁症（MDD）患者和 1170 例健康对照者进行 Trp64Arg 基因分型。其中，125 例精神分裂症患者、219 例 MDD 患者和 261 例对照者的体重指数（BMI）数据可用。
在诊断组之间，基因型或等位基因分布无显著差异。在 MDD 和对照组中，Arg 等位基因携带者和非携带者的 BMI 无显著差异。然而，携带 Arg 等位基因的精神分裂症患者的 BMI 显著更高（平均值（标准差）：Arg 携带者：26.5（6.9），Arg 非携带者：23.8（4.3）；P=0.019），超重率（BMI 为 25 或更高）也显著高于其对应者（Trp/Trp 组）（超重率（SE）：Arg 携带者：52.3（7.5），Arg 非携带者：32.1（5.2）；P=0.027）。
我们没有发现 ADRB3 Trp64Arg 与 MDD 或精神分裂症发展有关的证据。然而，Arg 等位基因与精神分裂症患者的 BMI 更高和超重有关。这可能意味着 ADRB3 基因分型在临床上可用于检测有肥胖风险的精神分裂症个体。
