Department of Biochemical Diagnostics, Medical University, Waszyngtona 15a, 15-269 Białystok, Poland.
Clin Chim Acta. 2012 Oct 9;413(19-20):1583-90. doi: 10.1016/j.cca.2012.05.009. Epub 2012 May 16.
Esophageal cancer (EC) is one of the most aggressive malignant tumors of the gastrointestinal tract. It is well known that cancer initiation and tumor development are closely linked with inflammation. C-reactive protein (CRP) and interleukin-6 (IL-6) are acute-phase proteins involved in cancer development. It was suggested that CRP and IL-6 play potential roles in the growth and progression of malignant tumors, including EC. The aim of the study was to describe the significance of IL-6 and CRP in the development of esophageal cancer and to assess the potential role of their serum levels as prognostic indicators of EC patient's survival.
食管癌（EC）是最具侵袭性的胃肠道恶性肿瘤之一。众所周知，癌症的发生和肿瘤的发展与炎症密切相关。C 反应蛋白（CRP）和白细胞介素-6（IL-6）是参与癌症发展的急性期蛋白。有研究表明，CRP 和 IL-6 在包括 EC 在内的恶性肿瘤的生长和进展中发挥着潜在作用。本研究旨在描述 IL-6 和 CRP 在食管癌发展中的意义，并评估其血清水平作为 EC 患者生存预后指标的潜在作用。
