Oberhoff Grace, Schooren Lena, Vondran Florian, Kroh Andreas, Koch Alexander, Bednarsch Jan, Neumann Ulf P, Schmitz Sophia M, Alizai Patrick H
Uniklinik Aachen, General-, Visceral- and Transplant Surgery, Pauwelsstr. 30, 52074 Aachen, Germany.
Uniklinik Aachen, Gastroenterology, Metabolic Diseases and Internal Intensive Care Medicine, Pauwelsstr. 30, 52074 Aachen, Germany.
Cancers (Basel). 2024 Jan 8;16(2):266. doi: 10.3390/cancers16020266.
Minimal-invasive resection of the esophagus for esophageal cancer has led to a relevant decrease in postoperative morbidity. Postoperatively, patients still suffer from surgical and adjuvant therapy-related symptoms impairing nutrition and quality of life. The aim of this study was to evaluate the nutritional status and associated symptoms six months after esophagectomy. Patients who attended follow-up examination six months after minimal-invasive esophagectomy were included. Blood and fecal tests, quality of life surveys (QLQ-C30 and QLQ-OG25) and nutritional risk screening (NRS) were performed. Twenty-four patients participated. The mean weight loss was 11 kg. A significant decrease in vitamin B12 (737 to 467 pg/mL; = 0.033), ferritin (302 to 126 ng/mL; = 0.012) and haptoglobin (227 to 152 mg/dL; = 0.025) was found. In total, 47% of the patients had an impaired pancreatic function (fecal elastase < 500 µg/g). Physical (72 to 58; = 0.034) and social functioning (67 to 40; = 0.022) was significantly diminished, while self-reported global health status remained stable (52 to 54). The number of patients screened and found to be in need of nutritional support according to NRS score decreased slightly (59% to 52%). After MIE, patients should be meticulously monitored for nutritional status after surgery.
食管癌的微创食管切除术已使术后发病率显著降低。术后，患者仍遭受与手术及辅助治疗相关的症状困扰，这些症状损害了营养状况和生活质量。本研究的目的是评估食管切除术后六个月的营养状况及相关症状。纳入了在微创食管切除术后六个月参加随访检查的患者。进行了血液和粪便检测、生活质量调查（QLQ-C30和QLQ-OG25）以及营养风险筛查（NRS）。24名患者参与。平均体重减轻11千克。发现维生素B12（从737降至467 pg/mL；P = 0.033）、铁蛋白（从302降至126 ng/mL；P = 0.012）和触珠蛋白（从227降至152 mg/dL；P = 0.025）显著下降。总体而言，47%的患者胰腺功能受损（粪便弹性蛋白酶<500 µg/g）。身体功能（从72降至58；P = 0.034）和社会功能（从67降至40；P = 0.022）显著降低，而自我报告的总体健康状况保持稳定（从52降至54）。根据NRS评分筛查出需要营养支持的患者数量略有下降（从59%降至52%）。微创食管切除术后，应对患者术后的营养状况进行细致监测。
