School of Pharmaceutical Science, Yantai University, Yantai 264005, PR China.
Fitoterapia. 2010 Oct;81(7):737-41. doi: 10.1016/j.fitote.2010.01.001. Epub 2010 Jan 15.
Two new neo-clerodane diterpenoids have been isolated from the whole plant of Scutellaria barbata D. Don, and their structures were established by detailed spectral analyses as scutehenanine H (1) and 6-(2,3-epoxy-2-isopropyl-n-propoxyl)barbatin C (2). In vitro, the isolated two new compounds showed significant cytotoxic activities against three human cancer lines, and gave IC(50) values in the range OF 2.0-4.2 μΜ.
从Scutellaria barbata D. Don 的全植物中分离得到两个新的 neo-clerodane 二萜类化合物，并通过详细的光谱分析确定它们的结构为 scutehenanine H（1）和 6-（2,3-环氧-2-异丙基-n-丙氧基）barbatin C（2）。体外实验表明，这两个新化合物对三种人癌细胞系具有显著的细胞毒性活性，其 IC50 值在 2.0-4.2 μM 范围内。
