Department of Organic Chemistry and Technology, University of Technology and Economics, H-1111 Budapest, Szt. Gellért tér 4, Hungary.
Molecules. 2012 May 18;17(5):5893-914. doi: 10.3390/molecules17055893.
The synthetic investigation of biologically active natural compounds serves two main purposes: (i) the total synthesis of alkaloids and their analogues; (ii) modification of the structures for producing more selective, more effective, or less toxic derivatives. In the chemistry of dimeric Vinca alkaloids enormous efforts have been directed towards synthesizing new derivatives of the antitumor agents vinblastine and vincristine so as to obtain novel compounds with improved therapeutic properties.
（i）生物碱及其类似物的全合成；（ii）结构修饰以产生更具选择性、更有效或毒性更低的衍生物。在二聚长春碱类生物碱的化学中，人们致力于合成抗肿瘤药物长春碱和长春新碱的新衍生物，以获得具有改善治疗性能的新型化合物。
