Dhyani Praveen, Quispe Cristina, Sharma Eshita, Bahukhandi Amit, Sati Priyanka, Attri Dharam Chand, Szopa Agnieszka, Sharifi-Rad Javad, Docea Anca Oana, Mardare Ileana, Calina Daniela, Cho William C
Department of Biotechnology, Kumaun University, Bhimtal, Uttarakhand, 263 136, India.
Facultad de Ciencias de la Salud, Universidad Arturo Prat, Avda. Arturo Prat 2120, 1110939, Iquique, Chile.
Cancer Cell Int. 2022 Jun 2;22(1):206. doi: 10.1186/s12935-022-02624-9.
Cancer, one of the leading illnesses, accounts for about 10 million deaths worldwide. The treatment of cancer includes surgery, chemotherapy, radiation therapy, and drug therapy, along with others, which not only put a tremendous economic effect on patients but also develop drug resistance in patients with time. A significant number of cancer cases can be prevented/treated by implementing evidence-based preventive strategies. Plant-based drugs have evolved as promising preventive chemo options both in developing and developed nations. The secondary plant metabolites such as alkaloids have proven efficacy and acceptability for cancer treatment. Apropos, this review deals with a spectrum of promising alkaloids such as colchicine, vinblastine, vincristine, vindesine, vinorelbine, and vincamine within different domains of comprehensive information on these molecules such as their medical applications (contemporary/traditional), mechanism of antitumor action, and potential scale-up biotechnological studies on an in-vitro scale. The comprehensive information provided in the review will be a valuable resource to develop an effective, affordable, and cost effective cancer management program using these alkaloids.
癌症是主要疾病之一，全球约有1000万人死于癌症。癌症的治疗方法包括手术、化疗、放疗和药物治疗等，这些治疗方法不仅给患者带来巨大的经济负担，而且随着时间的推移还会使患者产生耐药性。通过实施循证预防策略，可以预防/治疗大量癌症病例。在发展中国家和发达国家，植物源药物已成为有前景的预防性化疗选择。次生植物代谢产物如生物碱已被证明在癌症治疗中具有疗效和可接受性。关于此，本综述探讨了一系列有前景的生物碱，如秋水仙碱、长春碱、长春新碱、长春地辛、长春瑞滨和长春胺，涵盖了这些分子不同领域的全面信息，如它们的医学应用（现代/传统）、抗肿瘤作用机制以及体外潜在的扩大规模生物技术研究。综述中提供的全面信息将成为利用这些生物碱制定有效、可及且具有成本效益的癌症管理方案的宝贵资源。
